AIM To investigate the anti-proliferative effects of Crocus sativus extract and its major constituent, crocin, on three colorectal cancer cell lines (HCT-116, SW-480, and HT-29). The cell growth inhibition effect was compared to that of non-small cell lung cancer (NSCLC) cells. In addition, Crocus sativus' effect on non-cancer cells was evaluated. METHODS Using high performance liquid chromat...

Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative and medicinal herb. It has been considered as an alternative treatment for gastrointestinal diseases. C. sativus’ medicinal effects are associated to its major ingredients including crocin, crocetin and safranal. This study found that the gastrointestinal effects of C. sativus and its major ingre...

Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative and medicinal herb. It has been considered as an alternative treatment for cardiovascular diseases. C. sativus’ medicinal effects are associated to its major ingredients including crocin, crocetin and safranal. This study found that the cardiovascular effects of C. sativus and its major ingredien...

Crocin( Crocetin di-gentiobiose ester ) is the chemical constituent isolated from the Saffron, the dried trifid stigma of the plant Crocus sativus L. and also from the fruits of Gardenia(Gardenia jasminoides Ellis) It is found to be effective as antiproliferative, anti-oxidant, learning and memory enhancer, brain neurodegenerative disorder, sperm cryoconservation, biosurfactant, alzheimer disor...

Saffron or Crocus sativus L. (C. sativus) has been widely used as a medicinal plant to promote human health, especially in Asia. The main components of saffron are crocin, picrocrocin and safranal. The median lethal doses (LD50) of C. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. Saffron has been suggested to be effective in the treatment of a wide range of d...

BACKGROUND Apoptosis, a widely important mechanism that contributes to cell growth reduction, is reported to be induced by Crocus sativus in different cancer types. The present study was designed to elucidate apoptosis induction by crocin, a main component of Crocus sativus in a human pancreatic cancer cell line (BxPC-3). METHODS Cell viability was measured by MTT assay, Hoechest33258 stainin...

Oxidative stress damage to retinal pigment epithelial (RPE) cells is thought to play a critical role in the pathogenesis of age-related macular degeneration (AMD). Crocin, a pharmacologically active component of Crocus sativus L., was reported to have anti-antioxidant and anti-apoptotic properties. However, whether crocin protects against oxidative stress-induced retinal damage in RPE cells is ...

objective(s) anti-helicobacter pylori effects of saffron (crocus sativus l., iridacea) and its major constituents, crocin and safranal, were evaluated. materials and methods macerated aqueous and methanol extracts tested against 45 clinical isolates of helicobacter pylori, using paper disc diffusion method (ddm) on modified egg yolk emulsion agar (eye agar). four antibiotics also tested against...

Introduction: Bisphenol A (BPA) is a toxic chemical that is used as a monomer in the production of plastic products. The BPA has an endocrine-disrupting effect and ‎induces damage to the nervous system. Crocin, an active ingredient of Crocus sativus L. has ‎neuroprotective effects. Therefore, this study aimed to evaluate crocin’s effects on BPA-induced ‎memory impairment in rats and the levels ...

objective: saffron is the dried stigmas of crocus sativus l. which has various therapeutic properties in addition to its use as a spice. more than 80% of the world present production of saffron which is about 190 tons is produced in iran. to compare the quality of saffron' from different parts of the world, researcher used one sample from each country. since cultivation of saffron is done in di...